Primates and rodents, which descended from a common ancestor more than 90 million years ago, exhibit profound differences in behavior and cognitive capacity. Modifications, specializations and innovations to brain cell types may have occurred along each lineage and enabled evolutionary change.
We used single nuclei sequencing (Drop-seq) to profile RNA expression in more than 184,000 telencephalic interneurons from humans, macaques, marmosets and mice. Here we provide a simple tool for querying gene expression within neocortical interneuron datasets from adult mouse, marmoset, macaque and human. We also provide striatal interneuron gene expression from adult mouse, marmoset and human.
Within each region, interneurons from each species were aggregated into the main interneuron types based on expression of canonical conserved markers. Expression within each cell types is represented as the number of transcripts (for a given gene) per 100,000 transcripts.
For more details, see our manuscript .
Krienen, F.M., Goldman, M., Zhang, Q. et al. Innovations present in the primate interneuron repertoire. Nature (2020). https://doi.org/10.1038/s41586-020-2781-z
fenna_krienen at hms.harvard.edu
mccarroll at genetics.med.harvard.edu